The effects of pH on drug absorption in the gastrointestinal tract
December 20th, 2022
The effects of pH on drug absorption in the gastrointestinal tract
“To what extent does 6cm3 pH 1, 2, 3, 4, hydrochloric acid and pH 7 phosphate buffer affect the absorption of 200mg of Paracetamol, Aspirin, and Ibuprofen in the gastrointestinal tract, by utilizing the partition coefficient of aqueous solution and 4cm3 ethyl acetate to simulate the lipid component of tissues that line the gastrointestinal tract, and measuring the lambda max via UV Spectrophotometry?”
“To what extent does 6cm3 pH 1, 2, 3, 4, hydrochloric acid and pH 7 phosphate buffer affect the absorption of 200mg of Paracetamol, Aspirin, and Ibuprofen in the gastrointestinal tract, by utilizing the partition coefficient of aqueous solution and 4cm3 ethyl acetate to simulate the lipid component of tissues that line the gastrointestinal tract, and measuring the lambda max via UV Spectrophotometry?”
I have done some work but got stuck… here are my other questions:
1. What is the relationship between partition coefficient and bioavailability?
2. Is a high or low ratio in partition coefficient good or bad? what ratio means it absorbs better?
3. I am using pure paracetamol and pure aspirin, but ibuprofen from drug store. is the experiment feasible?
4. Should I use ethyl acetate or octanol?
